Danazol, used for treating abnormal uterine bleeding, suppresses which hormones?

• A. Gonadotropin-releasing hormone (GnRH)
• B. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH)
• C. Human chorionic gonadotropin (HCG) and luteinizing hormone
• D. Testosterone and estrogen

Answer: (B)

Danazol is a synthetic androgen that is used to treat various conditions, including endometriosis and abnormal uterine bleeding. Its mechanism of action involves the suppression of the hypothalamic-pituitary-gonadal (HPG) axis, which in turn decreases the levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

By inhibiting the release of these key gonadotropins from the pituitary gland, danazol effectively reduces ovarian estrogen and progesterone production, leading to atrophy of endometrial tissue and lessening symptoms associated with conditions like abnormal uterine bleeding. This suppression of FSH and LH is essential for achieving the therapeutic effects of danazol in managing estrogen-dependent conditions.

Other hormones mentioned in the choices do not align with the specific action of danazol. For instance, while gonadotropin-releasing hormone (GnRH) initiation is inhibited indirectly due to decreased levels of FSH and LH, it is not directly targeted by danazol. Similarly, human chorionic gonadotropin (HCG) plays a role in pregnancy and is not affected in the same manner as FSH and LH. While danazol is an androgen, it does not primarily act by suppressing testosterone