Spironolactone (Aldactone) is classified as which type of medication?

• A. Androgen agonist
• B. Estrogen agonist
• C. Progesterone antagonist
• D. Androgen receptor blocker

Answer: (D)

Spironolactone, commonly known by the brand name Aldactone, is primarily classified as an androgen receptor blocker. This medication is a potassium-sparing diuretic that has a unique mechanism of action. It antagonizes the effects of androgens on androgen receptors, which is beneficial in conditions related to androgen excess, such as polycystic ovary syndrome (PCOS) and hirsutism.

By blocking androgen receptors, spironolactone can help reduce symptoms associated with high levels of androgens, such as unwanted hair growth and acne. This receptor blockade also contributes to its diuretic effect by influencing the balance of electrolytes and fluid retention.

The other classifications listed, such as androgen agonist, estrogen agonist, and progesterone antagonist, do not accurately describe spironolactone’s function in the body. An androgen agonist would stimulate androgen receptors, which is opposite to what spironolactone does. Estrogen and progesterone agonists are related to the effects of female sex hormones, which are not within the scope of spironolactone’s action. Thus, understanding spironolactone's role as an androgen receptor blocker is crucial for comprehending its therapeutic uses