What class of drugs is typically used as a first-line treatment for polycystic ovarian syndrome-related hirsutism?

• A. Antibiotics
• B. Insulin sensitizers
• C. Oral contraceptives
• D. Androgen blockers

Answer: (C)

Oral contraceptives are often considered the first-line treatment for hirsutism associated with polycystic ovarian syndrome (PCOS) because they effectively lower androgen levels and help regulate menstrual cycles. PCOS is characterized by elevated levels of androgens, which can lead to symptoms such as hirsutism, acne, and irregular periods.

Combination oral contraceptives contain estrogen and progestin, which work together to suppress ovarian androgen production and improve the hormonal imbalance seen in PCOS. This reduction in androgen levels helps to alleviate hirsutism, making oral contraceptives an appropriate and effective first-line option for managing this condition.

Other treatment options, such as insulin sensitizers and androgen blockers, may also be beneficial in managing PCOS symptoms but are generally considered second-line therapies in the context of hirsutism. Insulin sensitizers, for example, primarily target insulin resistance associated with PCOS rather than directly addressing hirsutism.