What is a common adverse effect of Danazol, an androgen?

• A. Clitoral atrophy
• B. Weight loss
• C. Edema
• D. Breast tenderness

Answer: (C)

Danazol, an androgen, is often used in the treatment of conditions like endometriosis and fibrocystic breast disease. A common adverse effect associated with its use is edema, which can manifest as fluid retention and swelling in various parts of the body. This occurs due to the androgenic properties of Danazol, which can lead to increased sodium retention and decreased urinary excretion of water.

While other options like clitoral atrophy, weight loss, and breast tenderness may occur, they are less commonly reported compared to edema. Clitoral atrophy is a more specific side effect and does not occur in every patient. Weight loss may not be a frequent occurrence as well, given that Danazol can sometimes lead to weight gain due to fluid retention. Breast tenderness can happen as a side effect, but it is not as prevalent as generalized edema. Therefore, edema is the most recognized and common adverse effect of Danazol treatment, aligning with the pharmacological profile of this medication.