What is a common first-line medication for managing severe menopausal symptoms?

• A. Hormone replacement therapy (HRT)
• B. Selective serotonin reuptake inhibitors (SSRIs)
• C. Non-steroidal anti-inflammatory drugs (NSAIDs)
• D. Antidepressants

Answer: (A)

Hormone replacement therapy (HRT) is often recognized as a first-line treatment for managing severe menopausal symptoms, especially when these symptoms include hot flashes, night sweats, and vaginal dryness. HRT works by restoring estrogen levels in the body, which naturally decline during menopause. This therapy can effectively alleviate many of the discomforts associated with menopause, enhancing the quality of life for many women.

Estrogen replacement can be particularly beneficial for women who experience debilitating symptoms that interfere with daily activities. Additionally, HRT can help prevent osteoporosis, a condition that women are at increased risk for post-menopause due to the loss of protective estrogen.

While other treatment options, such as SSRIs and certain antidepressants, may also provide symptom relief, especially for mood instability associated with menopause, they are not typically the first line for managing physical menopausal symptoms like hot flashes. Non-steroidal anti-inflammatory drugs (NSAIDs) are primarily used for pain relief and do not address the underlying hormonal issues causing menopausal symptoms.

In summary, HRT directly targets the hormonal changes responsible for severe menopausal symptoms, making it the primary choice for those seeking relief.