What is the primary route of administration for depo-medroxyprogesterone acetate (DMPA)?

• A. Subcutaneous injection
• B. Intravenous injection
• C. Oral administration
• D. Intramuscular injection

Answer: (D)

The primary route of administration for depo-medroxyprogesterone acetate (DMPA) is through intramuscular injection. This method allows for a slow release of the medication into the bloodstream, providing effective hormonal contraception for an extended period, typically up to 3 months. The intramuscular route is advantageous because it ensures higher bioavailability compared to some other routes, leading to consistent and sustained levels of the drug in circulation.

While DMPA can also be administered subcutaneously, the intramuscular option is the most commonly used and well-established method in clinical practice. Other routes, such as oral administration, are not appropriate for DMPA since the medication requires a specific delivery method that achieves the desired pharmacokinetics for effective contraception.