What is the recommended administration interval for medroxyprogesterone acetate (Depo-Provera) in the prevention of pregnancy?

• A. 4 weeks
• B. 8 weeks
• C. 10 weeks
• D. 12 weeks

Answer: (D)

The recommended administration interval for medroxyprogesterone acetate, commonly known as Depo-Provera, in the prevention of pregnancy is 12 weeks. This long-acting injectable contraceptive is designed to be administered every three months to maintain effective contraceptive coverage. The formulation works by inhibiting ovulation, thickening cervical mucus, and thinning the endometrial lining, thus preventing pregnancy.

Administering the injection at 12-week intervals ensures that the hormone levels remain sufficiently elevated to prevent ovulation. If the injection is administered beyond the recommended interval, there is an increased risk of unintended pregnancy as hormone levels may drop below effective thresholds. Therefore, adherence to the 12-week schedule is critical for optimal efficacy in contraception.