What potential side effect could indicate the need for adjustment in hormone replacement therapy?

• A. Increased energy levels
• B. Weight loss
• C. Severe headaches
• D. Clear skin

Answer: (C)

Severe headaches serve as a critical indicator that may necessitate a reassessment of hormone replacement therapy (HRT). Headaches can be side effects associated with fluctuations in hormone levels, particularly estrogen. In women undergoing HRT, a sudden onset or significant increase in the frequency or severity of headaches could signify that the dosage or type of hormone being administered is not optimal for the individual.

Monitoring for adverse effects, like severe headaches, is essential in managing HRT, as this could also indicate an increased risk of complications, such as vascular issues. Adjusting the therapy can help alleviate these side effects and improve the overall effectiveness and safety of the treatment plan.

In contrast, increased energy levels, weight loss, and clear skin are typically not flags for complications arising from HRT. In fact, these outcomes might be considered positive effects of the therapy, suggesting proper hormonal balance rather than the need for adjustment.