Which drug class is contraindicated in pregnancy due to risk of fetal harm?

• A. Beta blockers
• B. ACE inhibitors
• C. Calcium channel blockers
• D. Antihistamines

Answer: (B)

ACE inhibitors are contraindicated in pregnancy primarily due to their potential to cause significant fetal harm. These medications, commonly used for managing hypertension and heart failure, can lead to adverse outcomes if taken during pregnancy, particularly in the second and third trimesters. The risks include fetal renal dysfunction, oligohydramnios, and even fetal death. Therefore, their use is avoided in pregnant women to ensure the safety and health of the developing fetus.

In contrast, while beta blockers, calcium channel blockers, and antihistamines may have some cautionary considerations in pregnancy, they do not carry the same level of risk for severe fetal harm as ACE inhibitors. For instance, some beta blockers can be used under careful supervision, and certain antihistamines are considered relatively safe during pregnancy. However, ACE inhibitors pose a particularly heightened risk, making them a clear contraindication during this critical period.