Which medication class is commonly prescribed to women for managing hot flashes?

• A. Beta-blockers
• B. Antidepressants
• C. Hormones
• D. Antihistamines

Answer: (B)

The most appropriate medication class commonly prescribed to women for managing hot flashes is hormones. Hormone therapy, specifically estrogen replacement therapy, is the most effective treatment for vasomotor symptoms, including hot flashes, that occur during menopause. Estrogens can significantly reduce the frequency and intensity of hot flashes and are shown to improve overall quality of life in postmenopausal women experiencing these symptoms.

While some antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), have been found to provide relief for hot flashes, they are not the first-line treatment compared to hormonal options. Non-hormonal treatments, including certain antidepressants, can be considered, especially in women who have contraindications for hormone therapy due to history of breast cancer or cardiovascular concerns.

Beta-blockers and antihistamines have not been shown to be effective for the specific treatment of hot flashes, making them less relevant in this context. Understanding these distinctions helps clarify why hormone therapy remains the most commonly prescribed and effective medication class for managing hot flashes in women.