Which medication is often used off-label for weight loss in women with PCOS?

• A. Glucophage
• B. Metformin
• C. Insulin
• D. Orlistat

Answer: (B)

Metformin is often used off-label for weight loss in women with polycystic ovary syndrome (PCOS) because it can help improve insulin sensitivity and reduce insulin levels, which are often elevated in this population. Women with PCOS frequently experience weight gain and have difficulty losing weight due to hormonal imbalances and insulin resistance, conditions that Metformin targets effectively.

By improving insulin sensitivity, Metformin can aid in the management of weight and can contribute to restoring ovulatory function, making it a beneficial option for many women with PCOS. It's important to note that while other medications may also be considered in the management of weight or related symptoms, Metformin’s unique mechanism of action in addressing both metabolic and reproductive aspects of PCOS makes it particularly relevant for weight management in this group.