Which medication is prescribed to help manage symptoms of premenstrual dysphoric disorder (PMDD)?

• A. Fluoxetine
• B. Ibuprofen
• C. Estradiol
• D. Metformin

Answer: (A)

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that is commonly used to treat major depressive disorders and is also effective in managing symptoms of premenstrual dysphoric disorder (PMDD). PMDD is a more severe form of premenstrual syndrome (PMS) and is characterized by significant mood disturbances as well as physical symptoms that can interfere with daily functioning. Fluoxetine works by increasing serotonin levels in the brain, which can help alleviate mood-related symptoms such as irritability, anxiety, and depressive moods that are commonly experienced in PMDD.

In contrast, ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is typically used to relieve pain and reduce inflammation. While it may help with physical symptoms associated with PMS, it does not address the psychological symptoms of PMDD. Estradiol, a form of estrogen, is used in hormone replacement therapy and some other conditions, but it may not directly alleviate the symptoms of PMDD. Metformin is primarily used to manage type 2 diabetes and polycystic ovary syndrome (PCOS), but it is not indicated for the treatment of PMDD. Thus, fluoxetine is the most appropriate choice for managing PMDD symptoms.