Which of the following nonhormonal treatments is known for alleviating menopausal symptoms?

• A. Benzodiazepines
• B. Copper intrauterine device
• C. Antiepileptic/antiseizure medications
• D. Selective serotonin reuptake inhibitors

Answer: (D)

Selective serotonin reuptake inhibitors (SSRIs) are well-documented for their effectiveness in alleviating menopausal symptoms, particularly hot flashes and mood disturbances. While SSRIs are primarily used as antidepressants, they have been found to have a positive effect on the frequency and severity of hot flashes in menopausal women. This is especially beneficial for women who may not be candidates for hormone replacement therapy (HRT) due to personal health factors or preferences.

The underlying mechanism involves the modulation of serotonin levels, which play a crucial role in regulating mood and the body’s thermoregulatory system. By increasing serotonin availability, SSRIs can help stabilize mood and improve coping strategies for menopausal symptoms, thus providing relief without the use of hormones.

Other treatment options mentioned, such as benzodiazepines and antiepileptic medications, do not have the same level of evidence supporting their use specifically for menopausal symptom relief. A copper intrauterine device is primarily utilized for contraception and not indicated for managing menopausal symptoms.