Which statement about hormone replacement therapy (HRT) in menopause is NOT true?

• A. The lowest dose for the shortest time should be used.
• B. Estrogen and progestin should be given together if the uterus is intact.
• C. Every woman should be placed on HRT for at least 2 years.
• D. Estrogen therapy is contraindicated with a history of breast cancer.

Answer: (C)

The statement that every woman should be placed on hormone replacement therapy (HRT) for at least 2 years is not true because HRT is not appropriate for all women, and the decision to use HRT should be individualized based on each woman’s specific health needs, risk factors, and personal preferences.

HRT is primarily used to manage menopause symptoms such as hot flashes, night sweats, and vaginal dryness. However, factors such as personal and family history of hormone-sensitive cancers, cardiovascular disease, thromboembolic events, and other contraindications can make HRT unsuitable for certain women. The duration and necessity of therapy should be carefully evaluated based on the severity of symptoms and the patient’s overall health status.

The guideline emphasizes using the lowest effective dose for the shortest duration needed to manage symptoms effectively and to have regular evaluations to determine whether continued HRT is necessary. These considerations highlight that a blanket recommendation for all women to use HRT for a minimum of two years does not align with current clinical practices and patient-centered approaches.